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GPC removes fats and other large, biomolecules from sample extracts.
The extraction process for determining semi volatile organic compounds in environmental samples is not very discriminating. It extracts the compounds of interest very well, along with any number of other constituents. These other constituents can be very detrimental to the performance of the analytical method, causing deposits in the injectors of GC and GCMS instrumentation, leading to erratic results.
Various cleanup techniques can be used to try to remove these interferences, but they are time-consuming, may remove target compounds, and cannot remove all interfering compounds. One of the primary classes of problem compounds are lipids, especially in tissue samples and soils with high levels of organic matter (e.g. ocean or river sediment.) Gel Permeation Chromatography (GPC) is very well-suited for removal of these compounds. GPC is a technique which separates components of a sample based on their molecular size. Since lipids are very large molecules compared to the target compounds in these methods, they are effectively removed from the extract prior to analysis. This improves method performance and extends GC column life, leading to more efficient analyses. With auto sampling and automatic fraction collection as part of the GPC system, the cleanups can be performed with little or no operator intervention, requiring only that the final extracts be concentrated down. For a quotation...
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