Electrospray mass spectrometry is a "soft" ionization technique which can be used to determine the molecular weight of many types of organic compounds. The main requirement is that the molecule can form an ion in solution under electrospray conditions. We have used this technique to determine molecular weights of ¹⁴C labeled compounds, demonstrating that they have been successfully labeled. Analysis of compounds which do not ionize easily may still be accomplished with the addition of a salt (usually ammonium formate) as a source of ions. In electrospray, these ions will frequently transfer a charge to the neutral analyte molecule, making it detectable as a protonated molecular ion (positively charged) or deprotonated molecular ion (negatively charged).

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