ppm Detection Limits with mg Sized Samples

Heavy metals by USP 231 generally requires large samples (0.5-1 g), too much for some very expensive drugs produced in small quantities such as proteins and peptides. Since ICPMS is the most sensitive technique for trace elements in solution, a 10 mg sample will give detection limits for most elements in the range of 0.01-1 ug/g (ppm). More than 60 elements can be determined in the same analysis which is a big advantage over GFAA where each element is done separately. We call this analysis an ICPMS Metals Screen.

Some proteins bind metals, and the metal assay is important for QC. Here again, using only very small samples, ICPMS can accurately assay the metal content. For injectable drugs, trace aluminum is an important element to monitor. Depending on the formulation, detection limits of 10 ug/L (ppb) or less can be achieved.

Typical detection limits for ICPMS are 0.01-1 ug/L (ppb) in solution. Sample preparation usually consists of simply diluting the sample in 1% nitric acid although we offer a variety of digestion techniques. For a quotation...